Applying a calcium phosphate layer on PEO/PBT copolymers affects bone formation in vivo
Identifieur interne : 000708 ( Main/Exploration ); précédent : 000707; suivant : 000709Applying a calcium phosphate layer on PEO/PBT copolymers affects bone formation in vivo
Auteurs : M. L. Gaillard [Pays-Bas] ; J. Van Den Brink [Pays-Bas] ; C. A. Van Blitterswijk [Pays-Bas] ; Z. B. Luklinska [Royaume-Uni]Source :
- Journal of Materials Science: Materials in Medicine [ 0957-4530 ] ; 1994-06-01.
Abstract
: Recently a copolymer (PolyactiveR) has been introduced that combines elastomeric and bone-bonding properties. Since calcification of the copolymer is a prerequisite for bone bonding. Polyactive was precalcified in vitro in order to increase the bone-bonding rate. Precalcification was performed by subsequent incubation in Ca and P solutions and resulted in formation of a hydroxyapatite layer on the surface of the implant. Within one week after implantation this layer had disappeared from the surface and a new calcification zone was formed under the surface of the copolymer. Longer implantation periods showed that in precalcified implants bone was apposited along the walls of the pores, while in control implants new bone was first formed in the centre of the pores. Consequently, the percentage of bone contact was increased in precalcified implants, however, the amount of bone ingrowth was equal in both control and precalcified implants. Transmission electron microscopy showed the presence of an electron-dense layer at the bone implant interface, which was indicative for bone-bonding. It is concluded from these experiments that precalcification of PEO/PBT copolymers affected the direction of bone apposition and increased the bone-bonding rate.
Url:
DOI: 10.1007/BF00058977
Affiliations:
- Pays-Bas, Royaume-Uni
- Angleterre, Grand Londres, Hollande-Méridionale
- Leyde, Londres
- Université de Londres
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Luklinska</name><affiliation wicri:level="4"><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>University of London, Department of Materials, Oueen Mary and Westfield College, Mile End Road, E1 4NS, London</wicri:regionArea><placeName><settlement type="city">Londres</settlement><region type="country">Angleterre</region><region type="région" nuts="1">Grand Londres</region></placeName><orgName type="university">Université de Londres</orgName></affiliation></author></analytic><monogr></monogr><series><title level="j">Journal of Materials Science: Materials in Medicine</title><title level="j" type="sub">Official Journal of the European Society for Biomaterials</title><title level="j" type="abbrev">J Mater Sci: Mater Med</title><idno type="ISSN">0957-4530</idno><idno type="eISSN">1573-4838</idno><imprint><publisher>Kluwer Academic Publishers</publisher><pubPlace>Dordrecht</pubPlace><date type="published" when="1994-06-01">1994-06-01</date><biblScope unit="volume">5</biblScope><biblScope unit="issue">6-7</biblScope><biblScope unit="page" from="424">424</biblScope><biblScope unit="page" to="428">428</biblScope></imprint><idno type="ISSN">0957-4530</idno></series><idno type="istex">28173E7EA7D41201173BCE080DE482EDFD12F9AE</idno><idno type="DOI">10.1007/BF00058977</idno><idno type="ArticleID">Art26</idno><idno type="ArticleID">BF00058977</idno></biblStruct></sourceDesc><seriesStmt><idno type="ISSN">0957-4530</idno></seriesStmt></fileDesc><profileDesc><textClass></textClass><langUsage><language ident="en">en</language></langUsage></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">: Recently a copolymer (PolyactiveR) has been introduced that combines elastomeric and bone-bonding properties. Since calcification of the copolymer is a prerequisite for bone bonding. Polyactive was precalcified in vitro in order to increase the bone-bonding rate. Precalcification was performed by subsequent incubation in Ca and P solutions and resulted in formation of a hydroxyapatite layer on the surface of the implant. Within one week after implantation this layer had disappeared from the surface and a new calcification zone was formed under the surface of the copolymer. Longer implantation periods showed that in precalcified implants bone was apposited along the walls of the pores, while in control implants new bone was first formed in the centre of the pores. Consequently, the percentage of bone contact was increased in precalcified implants, however, the amount of bone ingrowth was equal in both control and precalcified implants. Transmission electron microscopy showed the presence of an electron-dense layer at the bone implant interface, which was indicative for bone-bonding. It is concluded from these experiments that precalcification of PEO/PBT copolymers affected the direction of bone apposition and increased the bone-bonding rate.</div></front></TEI><affiliations><list><country><li>Pays-Bas</li><li>Royaume-Uni</li></country><region><li>Angleterre</li><li>Grand Londres</li><li>Hollande-Méridionale</li></region><settlement><li>Leyde</li><li>Londres</li></settlement><orgName><li>Université de Londres</li></orgName></list><tree><country name="Pays-Bas"><region name="Hollande-Méridionale"><name sortKey="Gaillard, M L" sort="Gaillard, M L" uniqKey="Gaillard M" first="M. L." last="Gaillard">M. L. Gaillard</name></region><name sortKey="Van Blitterswijk, C A" sort="Van Blitterswijk, C A" uniqKey="Van Blitterswijk C" first="C. A." last="Van Blitterswijk">C. A. Van Blitterswijk</name><name sortKey="Van Den Brink, J" sort="Van Den Brink, J" uniqKey="Van Den Brink J" first="J." last="Van Den Brink">J. Van Den Brink</name></country><country name="Royaume-Uni"><region name="Angleterre"><name sortKey="Luklinska, Z B" sort="Luklinska, Z B" uniqKey="Luklinska Z" first="Z. B." last="Luklinska">Z. B. Luklinska</name></region></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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